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Science 31 January 1964:
Vol. 143. no. 3605, pp. 474 - 475
DOI: 10.1126/science.143.3605.474
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Articles

Identity of Tarichatoxin and Tetrodotoxin

H. Dieter Buchwald 1, Lois Durham 1, Hans G. Fischer 1, Rockuro Harada 1, Harry S. Mosher 1, C. Y. Kao 2, and Frederick A. Fuhrman 3

1 Department of Chemistry, Stanford University, Stanford, California
2 Department of Pharmacology, State University of New York, Brooklyn
3 School of Medicine, Stanford University, Palo Alto, California

Tarichatoxin (C11H17N3O8), a potent neurotoxin recently isolated in pure form from the eggs of the California newt, Taricha torosa, has been found to be identical to tetrodotoxin from the ovaries of Sphoeroides rubripes, the Japanese Fugu or puffer fish. As yet this substance has been detected only in a single family of fish, Tetraodontidae, and in a single family of amphibia, Salamandridae.


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Tarichatoxin-Tetrodotoxin: A Potent Neurotoxin.
H. S. Mosher, F. A. Fuhrman, H. D. Buchwald, and H. G. Fischer (1964)
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Science. ISSN 0036-8075 (print), 1095-9203 (online)