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Science 24 January 1964:
Vol. 143. no. 3604, pp. 371 - 373
DOI: 10.1126/science.143.3604.371
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Articles

Oxidation of Carbon-14-Labeled Endogenous Lipids by Isolated Perfused Rat Heart

Joseph C. Shipp 1, James M. Thomas 1, and Lamar Crevasse 1

1 Department of Medicine, University of Florida School of Medicine, Gainesville

Lipids of the rat heart were labeled with carbon-14 in vivo. The production of C14O2 during the subsequent perfusion of these glycogen-depleted hearts with buffer, but without added substrate, provided direct evidence of the oxidation of endogenous heart lipids. The net decrease in phospholipid content alone could account for 75 percent of the total metabolic CO2 formed.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)