Hemoglobin Solubility and
-Chain Structure in Crosses between Two Inbred Mouse Strains
John J. Hutton 1,
Richard S. Schweet 1,
H. Glenn Wolfe 2, and
Elizabeth S. Russell 2
1 University of Kentucky College of Medicine, Lexington
2 Jackson Laboratory, Bar Harbor, Maine
In genetic crosses between mouse strains with low and high solubilities of hemoglobin, solubility segregated as a Mendelian unit and appeared to be determined by the alleles controlling
-chain structure. New data eliminate close linkage between the
-chain locus and genetic markers in linkage groups Ill, IV, XI, XIII, and XVI. Simplified methods are presented for screening differences in
-chain peptides and solubility.