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Science 17 January 1964:
Vol. 143. no. 3603, pp. 252 - 253
DOI: 10.1126/science.143.3603.252

Articles

Hemoglobin Solubility and agr-Chain Structure in Crosses between Two Inbred Mouse Strains

John J. Hutton 1, Richard S. Schweet 1, H. Glenn Wolfe 2, and Elizabeth S. Russell 2

1 University of Kentucky College of Medicine, Lexington
2 Jackson Laboratory, Bar Harbor, Maine

In genetic crosses between mouse strains with low and high solubilities of hemoglobin, solubility segregated as a Mendelian unit and appeared to be determined by the alleles controlling agr-chain structure. New data eliminate close linkage between the agr-chain locus and genetic markers in linkage groups Ill, IV, XI, XIII, and XVI. Simplified methods are presented for screening differences inagr-chain peptides and solubility.





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Science. ISSN 0036-8075 (print), 1095-9203 (online)