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Science 10 January 1964:
Vol. 143. no. 3602, pp. 143 - 144
DOI: 10.1126/science.143.3602.143
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Articles

Vitamin D3: Direct Action on the Small Intestine of the Rat

David Schachter 1, Szloma Kowarski 1, and James D. Finkelstein 1

1 Department of Medicine, College of Physicians and Surgeons of Columbia University and Presbyterian Hospital, New York, New York

Vitamin D3 placed directly into loops of rat duodenum in vitamin D deficient animals increases markedly the subsequent transport of calcium by slices of the duodenal loop in vitro. Under similar conditions the same dose of vitamin given intravenously or placed in a jejunal loop has little or no effect on the duodenal tissue. Thus the vitamin acts directly on the small intestine without prior activation in another organ.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The Nature of Vitamin D Resistance of Patients With Chronic Renal Disease.
L. V. Avioli, S. J. Birge, and E. Slatopolsky (1969)
Arch Intern Med 124, 451-454
   Abstract »    PDF »
Recent Progress in Osteomalacia and Rickets.
A. R. ARNSTEIN, B. FRAME, and H. M. FROST (1967)
Ann Intern Med 67, 1296-1330
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)