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Science 3 January 1964:
Vol. 143. no. 3601, pp. 47 - 49
DOI: 10.1126/science.143.3601.47
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Articles

Circularity of the Replicating Form of a Single-Stranded DNA Virus

Barbara Chandler 1, M. Hayashi 2, M. N. Hayashi 2, and S. Spiegelman 2

1 Department of Zoology, University of Wisconsin, Madison
2 Department of Microbiology, University of Illinois, Urbana

Electron micrographs of purified replicating form DNA of the bacteriophage øX-174 show that it has ring structure. The circular property may explain both the abnormally high sedimentation coefficient and the great resistance of this DNA to irreversible heat denaturation. Intactness of the circle is required for the control of strand selection during transcription into complementary copies of RNA.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Chemistry and Structure of Nucleic Acids of Bacteriophages: Many forms of nucleic acids of bacteriophages show the ways that information is stored and reproduced.
J. A. Cohen (1967)
Science 158, 343-351
   Abstract »    PDF »
Allomorphic Forms of Bacteriophage oX-174 Replicative DNA.
T. F. Roth and M. Hayashi (1966)
Science 154, 658-660
   Abstract »    PDF »
Electron Microscopy of Single-Stranded DNA: Circularity of DNA of Bacteriophage phiX174.
D. Freifelder, A. K. Kleinschmidt, and R. L. Sinsheimer (1964)
Science 146, 254-255
   Abstract »    PDF »


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