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Science 3 January 1964:
Vol. 143. no. 3601, pp. 42 - 44
DOI: 10.1126/science.143.3601.42
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Articles

Intestinal Invertase: Precocious Development of Activity after Injection of Hydrocortisone

Ruth G. Doell 1 and Norman Kretchmer 1

1 Department of Pediatrics, Stanford University School of Medicine, Palo Alto, California

Injection of rats aged 3 to 9 days with hydrocortisone causes precocious development of invertase activity in the small intestine. The enzyme becomes fully active about 72 hours after injection of hydrocortisone. Invertase activity is also detectable when hydrocortisone is added to organ culture of intestine derived from 5-to 6-day old rats. Hydrocortisone does not appear to affect the activity of lactase, suggesting that it does not act solely by hastening the normal maturation process.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Glucocorticoids have pleiotropic effects on small intestinal crypt cells.
A. Quaroni, J. Q. Tian, M. Goke, and D. K. Podolsky (1999)
Am J Physiol Gastrointest Liver Physiol 277, G1027-G1040
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Intestinal Maturation in the Rat: The Role of Enteral Nutrients.
R. O. Castillo, A. Pittler, and F. Costa (1988)
JPEN J Parenter Enteral Nutr 12, 490-495
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The Effects of Steroids Upon the Gastrointestinal Tract.
H. E. Black (1988)
Toxicol Pathol 16, 213-222
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Intestinal Lactase Activity in the Suckling Rat: Influence of Hypophysectomy and Thyroidectomy.
K.-Y. Yeh and F. Moog (1974)
Science 183, 77-79
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Environmental Influence on Intrauterine Lung Development.
J. H. Knelson (1971)
Arch Intern Med 127, 421-425
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Intestinal Enzymes: Indicators of Proliferation and Differentiation in the Jejunum.
R. Fortin-Magana, R. Hurwitz, J. J. Herbst, and N. Kretchmer (1970)
Science 167, 1627-1628
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Developmental Biology.
N. Kretchmer (1969)
Arch Pediatr Adolesc Med 118, 836-846
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Science. ISSN 0036-8075 (print), 1095-9203 (online)