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Science 27 December 1963:
Vol. 142. no. 3600, pp. 1657 - 1658
DOI: 10.1126/science.142.3600.1657
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Articles

Drug-Induced Changes in the Liver Endoplasmic Reticulum: Association with Drug-Metabolizing Enzymes

H. Remmer 1 and H. J. Merker 1

1 Department of Pharmacology and Institute for Electronmicroscopy, Freien Universiät, Berlin-Dahlem, Germany

The cellular changes which lead to the increase of drug-metabolizing enzymes following drug administration are explained by correlating new biochemical data with previously reported electron microscopic and pharmacologic observations. Repeated administration of phenobarbital and several other drugs results in a quantitative increase of the smooth endoplasmic reticulum of the liver cell. The marked increase in drug-metabolizing enzymes is found to occur in this enlarged smooth membrane fraction of the endoplasmic reticulum.


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