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Science 13 December 1963:
Vol. 142. no. 3598, pp. 1474 - 1476
DOI: 10.1126/science.142.3598.1474
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Articles

Poisoning by DDT: Relation between Clinical Signs and Concentration in Rat Brain

William E. Dale 1, Thomas B. Gaines 1, Wayland J. Hayes Jr. 1, and Geroge W. Pearce 2

1 Communicable Disease Center, U.S. Public Health Service, Atlanta, Georgia George W. Pearce
2 Communicable Disease Center, U.S. Public Health Service, Savannah, Georgia

The severity of signs of poisoning in rats after a single dose of DDT is directly proportional to the concentration of the compound in their brains. The concentrations associated with death after one large dose are about the same as those after many smaller doses.


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