Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 13 December 1963:
Vol. 142. no. 3598, pp. 1468 - 1469
DOI: 10.1126/science.142.3598.1468
Prev | Table of Contents | Next

Articles

Erythroid Homeostasis in Normal and Genetically Anemic Mice: Reaction to Induced Polycythemia

Ronald L. Niece 1, Eleanor C. McFarland 2, and Elizabeth S. Russell 2

1 Blackburn College, Carlinville, Illinois
2 Jackson Laboratory, Bar Harbor, Maine

After hypertransfusion, normal ww and anemic WWT mice show the same increase in red-cell volume, decrease in reticulocytes, and temporary cessation of blood formation. The time required for the red cell volume to return to the value observed before treatment is the same for both groucps of inice. The cell volume at which new erythrocytes are again released into the circulation depends upon the genotype of functioning blood-forming tissue. Injections of erythropoietin stimulate red cell formation in polycythemic ww mice, but have much less (if any) effect upon polycythemic WWT mice.

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)