Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 29 November 1963:
Vol. 142. no. 3596, pp. 1180 - 1181
DOI: 10.1126/science.142.3596.1180
Prev | Table of Contents | Next

Articles

Separation of Transducer and Impulse-Generating Processes in Sensory Receptors

W. R. Loewenstein 1, C. A. Terzuolo 2, and Y. Washizu 2

1 Department of Physiology, College of Physicians and Surgeons, Columbia University, New York
2 Department of Physiology, Medical School, University of Minnesota, Minneapolis

New evidence is presented that spike and transducer processes in sensory receptors are independent events; impulse activity in tile crustacean stretch receptor neuron and the mammalian pacinian corpuscle was selectively blocked by a compound (tetrodotoxin) without affecting any of the parameters of the generator potential.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Fatigue and Paradoxical Enhancement of Heat Response in C-Fiber Nociceptors from Cross-Modal Excitation.
Y. B. Peng, M. Ringkamp, R. A. Meyer, and J. N. Campbell (2003)
J. Neurosci. 23, 4766-4774
   Abstract »    Full Text »    PDF »
Action Potential and Sodium Current in the Slowly and Rapidly Adapting Stretch Receptor Neurons of the Crayfish (Astacus astacus).
N. Purali and B. Rydqvist (1998)
J Neurophysiol 80, 2121-2132
   Abstract »    Full Text »    PDF »
Development of a Receptor on a Foreign Nerve Fiber in a Pacinian Corpuscle.
J. Schiff and W. R. Loewenstein (1972)
Science 177, 712-715
   Abstract »    PDF »
Tetrodotoxin: Effects on Brain Metabolism in vitro.
S. L. Chan and J. H. Quastel (1967)
Science 156, 1752-1753
   Abstract »    PDF »
Tetrodotoxin: Action on Graded Responses.
H. Grundfest and R. M. Benolken (1967)
Science 156, 1771
   PDF »
Tetrodotoxin Blocks a Graded Sensory Response in the Eye of Limulus.
R. M. Benolken and C. J. Russell (1967)
Science 155, 1576-1577
   Abstract »    PDF »
Tetraethylammonium and Tetrodotoxin: Effects on Cochlear Potentials.
Y. Katsuki, K. Yanagisawa, and J. Kanzaki (1966)
Science 151, 1544-1545
   Abstract »    PDF »
Electrophysiology and Pharmacology of Different Components of Bioelectric Transducers.
H. Grundfest (1965)
Cold Spring Harb Symp Quant Biol 30, 1-14
   Abstract »    PDF »
Facets of a Transducer Process.
W. R. Loewenstein (1965)
Cold Spring Harb Symp Quant Biol 30, 29-43
   Abstract »    PDF »
An Insect Mechanoreceptor: Part II: Receptor Potentials.
U. Thurm (1965)
Cold Spring Harb Symp Quant Biol 30, 83-94
   Abstract »    PDF »
A Physiologic and Pharmacologic Study of Olfactory Receptors.
D. Tucker and T. Shibuya (1965)
Cold Spring Harb Symp Quant Biol 30, 207-215
   Abstract »    PDF »
Adaptation in Stretch Receptor Neurons of Crayfish.
S. Nakajima (1964)
Science 146, 1168-1170
   Abstract »    PDF »
Eel Electroplaques: Spike Electrogenesis without Potassium Activation.
Y. Nakamura, S. Nakajima, and H. Grundfest (1964)
Science 146, 266-268
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)