Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 29 November 1963:
Vol. 142. no. 3596, pp. 1172 - 1173
DOI: 10.1126/science.142.3596.1172
Prev | Table of Contents | Next

Articles

Homograft Rejection in the Fetal Lamb: The Role of Circulating Antibody

Arthur M. Silverstein 1, Robert A. Prendergast 1, and Keith L. Kraner 1

1 Armed Forces Institute of Pathology, Washington, D. C. 20305

Specific rejection of sterile orthotopic skin homografts by the fetal lamb in utero was unaccompanied by the presence of plasma cells in either the graft and its bed, or in the reactive draining lymph node. The grafts appeared not to stimulate the production of circulating immunoglobulins. The presence in the fetal circulation of rabbit anti-sheep 7S ggr-globulin and anti-beta2M-globulin did not inhibit the normal course of homograft rejection. These data support the contention that conventional circulating antibody is not an obligatory participant in the rejection of solid-tissue homografts.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Transplantation of fetal hematopoietic stem cells in utero: the creation of hematopoietic chimeras.
A. Flake, M. Harrison, N. Adzick, and E. Zanjani (1986)
Science 233, 776-778
   Abstract »    PDF »
Ontogeny of the Immune Response.
A. M. Silverstein (1964)
Science 144, 1423-1428
   PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)