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Science 22 November 1963:
Vol. 142. no. 3595, pp. 1075 - 1076
DOI: 10.1126/science.142.3595.1075
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Articles

Lactic Dehydrogenase: Genetic Control in Mana

Walter E. Nance 1, Alice Claflin 1, and Oliver Smithies 1

1 Department of Medical Genetics, University of Wisconsin, Madison

A genetically determined variant of lactic dehydrogenase has been observed in the red cells of four members of two generations of a Brazilian family. The appearance of the variant after starch-gel electrophoresis of the hemolysates supports the concept that the lactic dehydrogenase isozymes are determined by the interaction of two subunits which are under separate genetic control. The products of the mutant and normal allele do not, however, appear to associate randomly to form isozymes. The similarity of the relative retardation of normal and mutant isozymes in gels made with increasing concentrations of starch suggests that they do not differ significantly in size.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Genetic Determination of Phenotypic Variation in Sickle Cell Trait.
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Linkage of Lactate Dehydrogenase B and C Loci in Pigeons.
W. H. Zinkham, H. Isensee, and J. H. Renwick (1969)
Science 164, 185-187
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Molecular Aspects of Lens Cell Differentiation.
J. Papaconstantinou (1967)
Science 156, 338-346
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Lactate Dehydrogenase of Trout: Hybridization in vivo and in vitro.
E. Goldberg (1966)
Science 151, 1091-1093
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Polymorphism of Lactate Dehydrogenase in Gelada Baboons.
F. N. Syner and M. Goodman (1966)
Science 151, 206-208
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Lactate Dehydrogenase Isozyme Patterns of Human Platelets and Bovine Lens Fibers.
E. S. Vesell (1965)
Science 150, 1735-1737
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Electrophoretic Variation in Enzymes.
C. R. Shaw (1965)
Science 149, 936-943
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Polymorphism of Human Lactate Dehydrogenase Isozymes.
E. S. Vesell (1965)
Science 148, 1103-1105
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Lactate Dehydrogenases in Trout: Evidence for a Third Subunit.
E. Goldberg (1965)
Science 148, 391-392
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Human Erythrocyte Lactate Dehydrogenase: Four Genetically Determined Variants.
A. P. Kraus and C. L. Neely Jr. (1964)
Science 145, 595-597
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Lactate Dehydrogenase in Pigeon Testes: Genetic Control by Three Loci.
W. H. Zinkham, A. Blanco, and L. Kupchyk (1964)
Science 144, 1353-1354
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)