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Science 1 November 1963:
Vol. 142. no. 3592, pp. 590 - 591
DOI: 10.1126/science.142.3592.590
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Articles

Hepatic Glucokinase: A Direct Effect of Insulin

John W. Vester 1 and Mary L. Reino 1

1 Departments of Medicine and Biochemistry, University of Pittsburgh School of Medicine, and Veterans Administration Hospital, Pittsburgh 40, Pennsylvania

Particle-free extracts of the livers from rats on a normal diet were incubated with insulin for 4 minutes; during this time the glucokinase activity increased. This insulin effect is dependent upon the dose.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)