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Science 25 October 1963:
Vol. 142. no. 3591, pp. 490 - 491
DOI: 10.1126/science.142.3591.490
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Articles

Abnormal Myoglobin Ultraviolet Spectrum in Duchenne Type of Progressive Muscular Dystrophy

Kazuo Miyoshi 1, Kazuo Saijo 1, Yojiro Kuryu 1, and Yasuo Oshima 1

1 Department of Internal Medicine, School of Medicine, Tokushima University, Tokushima, Japan

Met-myoglobin isolated from gluteal muscle of cases with Duchenne type of progressive muscular dystrophy showed an abnormal ultraviolet spectrum. The maximum of the spectrum at pH 7.0 was at 275 mµ, in contrast to that at 281 m/ A in normal met-myoglobin. Such an abnormality was not found in the limb-girdle type of dystrophy and in progressive spinal muscular atrophy. The results indicate the presence of an abnormal myoglobin in the Duchenne type of progressive muscular dystrophy.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Myoglobin Subfractions: Abnormality in Duchenne Type of Progressive Muscular Dystrophy.
K. Miyoshi, K. Saijo, Y. Kuryu, Y. Oshima, M. Nakano, and H. Kawai (1968)
Science 159, 736-737
   Abstract »    PDF »
Myoglobin and Muscular Dystrophy: Electrophoretic and Immunochemical Study.
L. P. Rowland, P. B. Dunne, A. S. Penn, and E. Maher (1968)
Arch Neurol 18, 141-150
   Abstract »    PDF »
Protein Abnormalities in Neuromuscular Diseases--Part 2.
W. K. Engel, D. E. McFarlin, G. A. Drews, and R. D. Wochner (1966)
JAMA 195, 837-842
   Abstract »    PDF »
A Study of Myoglobin in Disease with Comments Concerning the Myoglobin Minor Components.
R. J. Kossman, D. C. Fainer, and S. H. Boyer (1964)
Cold Spring Harb Symp Quant Biol 29, 375-385
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)