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Science 25 October 1963:
Vol. 142. no. 3591, pp. 488 - 490
DOI: 10.1126/science.142.3591.488
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Articles

Inhibition by 5-Iododeoxyuridine of the Oncogenic Effects of Adenovirus Type 12 in Hamsters

R. J. Huebner 1, W. T. Lane 1, A. D. Welch 2, P. Calabresi 2, R. W. McCollum 2, and W. H. Prusoff 2

1 National Institute of Allergy and Infectious Diseases, Bethesda 14, Maryland
2 Yale University School of Medicine, New Haven, Conn.

Subcutaneous tumors induced in newborn hamsters by type 12 adenovirus were suppressed when 0.5 mg of 5-iodo-2'-deoxyuridine (IUdR) was given at the same subcutaneous site as the virus. Although one injection of IUdR given immediately after the virus was effective, additional injections on subsequent days reduced further the number of hamsters developing tumors. These effects of lUdR are especially interesting since replication of infectious adenovirus 12 cannot be demonstrated in the hamsters at any time before or after tumor development.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Newer Compounds in Therapy of Herpes Simplex Keratitis.
R. A. Hyndiuk and H. E. Kaufman (1967)
Arch Ophthalmol 78, 600-605
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Science. ISSN 0036-8075 (print), 1095-9203 (online)