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Science 18 October 1963:
Vol. 142. no. 3590, pp. 400 - 401
DOI: 10.1126/science.142.3590.400
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Articles

Genetic Differences in Antibody Production to Determinant Groups on Insulin

Edward R. Arquilla 1 and Jack Finn 1

1 Department of Pathology, School of Medicine, University of California, Los Angeles

Highly inbred strain 2 guinea pigs can produce antibodies to portions of the insulin molecule to which strain 13 guinea pigs cannot produce antibodies. Such differences were not observable within either strain. Consequently it is probable that genetic factors regulate antibody production with respect to the determinant groups toward which antibodies are directed.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Summary: Understanding Selective Molecular Recognition.
G. M. Edelman (1977)
Cold Spring Harb Symp Quant Biol 41, 891-902
   Abstract »    PDF »
Antibodies against the Component Polypeptide Chains of Bovine Insulin.
Y. Yagi, P. Maier, and D. Pressman (1965)
Science 147, 617-619
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)