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Science 18 October 1963:
Vol. 142. no. 3590, pp. 392 - 393
DOI: 10.1126/science.142.3590.392
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Articles

Delayed Incorporation of Tritiated Thymidine into DNA

Stephen H. Robinson 1 and George Brecher 1

1 Clinical Center, National Institutes of Health, Bethesda 14, Maryland

Delayed utilization of tritiated thymidine by regenerating mouse liver can be almost completely suppressed by a continuous infusion of nonradioactive thymidine. In addition, as shown earlier for lymphocytes, labeled granulocytes are a potential source of the tritium marker. These observations suggest that the delayed incorporation of label into DNA must be due to the transfer of labeled nucleoside, which may be derived either from the degradation of DNA or from a long-lived intracellular pool. In either case, the transferred material probably originates from all tissues that have a high rate of cell turnover.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Chimeric Mice with Donor-Type Liver Cells.
R. C. Hard Jr. and B. Kullgren (1966)
Science 152, 349-352
   Abstract »    PDF »
Kinetics of Deoxyribonucleic Acid Synthesis within the Inner Enamel Epithelium.
R. E. Stallard, M. A. Diab, and H. A. Zander (1966)
Journal of Dental Research 45, 315-322
   PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)