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Science 18 October 1963:
Vol. 142. no. 3590, pp. 390 - 392
DOI: 10.1126/science.142.3590.390
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Articles

Actinomycin: Inhibition of Cortisone-Induced Synthesis of Hepatic Gluconeogenic Enzymes

George Weber 1, Radhey L. Singhal 1, and Nancy B. Stamm 1

1 Department of Pharmacology, Indiana University School of Medicine, Indianapolis 46207

The cortisone-induced de novo synthesis of liver glucose-6-phosphatase, fructose-1, 6-diphosphatase, aldolase, and lactic dehydrogenase was prevented by injections of Actinomycin D in the rat. In the in vitro assay systems, addition of actinomycin exerted no effect on the enzyme activities examined. The evidence favors the concept that the increased gluconeogenesis induced by corticoids entails at a certain stage an increased rate in the synthesis of gluconeogenic enzymes.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Insulin Action in Alloxan Diabetes Modified by Actinomycin D.
A. Gellhorn and W. Benjamin (1964)
Science 146, 1166-1168
   Abstract »    PDF »
Induction of Several Adaptive Enzymes by Actinomycin D.
F. Rosen, P. N. Raina, R. J. Milholland, and C. A. Nichol (1964)
Science 146, 661-663
   Abstract »    PDF »
Intestinal Phosphatase Activity: Acceleration of Increase by Puromycin and Actinomycin.
F. Moog (1964)
Science 144, 414-416
   Abstract »    PDF »
Glycogen Synthetase: Its Response to Cortisol.
H.-G. Sie and W. H. Fishman (1964)
Science 143, 816-817
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)