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Science 20 September 1963:
Vol. 141. no. 3586, pp. 1193 - 1194
DOI: 10.1126/science.141.3586.1193
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Articles

Thymectomy: Prolongation of Immunological Tolerance in the Adult Mouse

Henry N. Claman 1 and David W. Talmage 1

1 Department of Medicine, University of Colorado Medical Center, Denver 20

The loss of acquired immunological tolerance of mice to bovine gamma globulin depended on the presence of the thymus. Mice were repeatedly injected with bovine ggr-globulin from birth until the age of 5 to 10 weeks and then thymectomized or sham operated. After 130 to 160 days without antigen, an accelerated (immune) disappearance of I125 bovine ggr-globulin could be uniformly induced in controls while thymectomized mice remained tolerant. Adult thymectomized mice made tolerant by a single injection of bovine ggr-globulin lost tolerance more slowly than sham-operated controls.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Tolerization of Mice to Schistosoma mansoni Egg Antigens Causes Elevated Type 1 and Diminished Type 2 Cytokine Responses and Increased Mortality in Acute Infection.
P. G. Fallon and D. W. Dunne (1999)
J. Immunol. 162, 4122-4132
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Immunological Competence: Alteration by Whole Body X-Irradiation and Shielding of Selected Lymphoid Tissues.
J. Miller (1966)
Science 151, 1395-1397
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Adult Thymectomy: Effect on Recovery from Immunologic Depression in Mice.
A. P. Monaco, M. L. Wood, and P. S. Russell (1965)
Science 149, 432-435
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Immunologic Tolerance in Thymectomized, Irradiated Rats Grafted with Thymus from Tolerant Donors.
K. Isakovicacute, S. B. Smith, and B. H. Waksman (1965)
Science 148, 1333-1335
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The Thymus and the Development of Immunologic Responsiveness.
J. F. A. P. Miller (1964)
Science 144, 1544-1551
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