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Science 20 September 1963:
Vol. 141. no. 3586, pp. 1188 - 1190
DOI: 10.1126/science.141.3586.1188
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Articles

Tremorine: Its Effect on Amines of the Central Nervous System

Alexander H. Friedman 1, Robert J. Aylesworth 1, and Gertrud Friedman 1

1 Department of Pharmacology and Toxicology, University of Wisconsin Medical School, Madison 6

The administration of tremogenidine doses of Tremorine, 1,4-dipyrrolidino-2 butyne, is followed by a significant decrease in the concentration of norepinephrine in the brain stem of three common laboratory species. The change in the concentration proceeds at a rate which coincides with the occurrence of the tremor in each of these species. In the rat, the change in norepinephrine is followed by a progressive increase in the concentration of 5-hydroxytryptamine in the brain stem. Bilateral adrenalectomy in the rat enhances the Tremorine-induced changes in the concentration of norepinephrine and antagonizes the increase in the concentration of S-hydroxytryptamine.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)