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Science 20 September 1963:
Vol. 141. no. 3586, pp. 1181 - 1182
DOI: 10.1126/science.141.3586.1181
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Articles

Temperature-Dependent Histotypic Changes in Walker Carcinosarcoma in the Chorioallantois

Joseph Leighton 1, Leonard Merkow 1, and Gerald Justh 1

1 Department of Pathology, School of Medicine, University of Pittsburgh Pittsburgh 13, Pennsylvania

Solid tumors grew in the chorioallantois of chick embryos after the topical inoculation of ascites tumor cells. The microscopic character of the growth varied depending on the temperature of incubation. At 32.5°C a sarcomatous appearance was prominent; at 37.5°C carcinomatous structure in several alveolar patterns predominated; at 42.5°C growth was that of a "giant cell" carcinoma.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)