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Science 13 September 1963:
Vol. 141. no. 3585, pp. 1061 - 1063
DOI: 10.1126/science.141.3585.1061
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Articles

Circulating Interferon in Mice after Intravenous Injection of Virus

Samuel Baron 1 and Charles E. Buckler 1

1 Laboratory of Biology of Viruses, National Institute of Allergy andInfectious Diseases, Bethesda 14, Maryland

Circulating interferon was detectable in mouse serum within 1 hour after the intravenous injection of various types of virus and it reached maximum levels in about 4 hours. Rapidly produced interferon may play a role in the pathogenesis of viral infection and in viral interference.


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