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Science 6 September 1963:
Vol. 141. no. 3584, pp. 907 - 908
DOI: 10.1126/science.141.3584.907
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Articles

Bradykinin: Vascular Relaxant, Cardiac Stimulant

Drogo Montague 1, Ramon Rosas 1, and David F. Bohr 1

1 Department of Physiology, University of Michigan, Ann Arbor

Bradykinin infusion causes an increase in cardiac output in rats whether the autonomic nervous system is blocked or not. After autonomic blockade, bradykinin causes a lesser decrease in the total peripheral resistance but a greater increase in cardiac output, resulting in an elevation of arterial pressure. The increase in cardiac output is caused by a small increase in heart rate and a substantial increase in stroke volume. The fact that these increases are observed after autonomic blockade suggests that bradykinin increases cardiac output by direct stimulation of the heart.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Angiotensin-Converting Enzyme Inhibitors an Angiotensin II-Receptor Antagonists.
M. Pfaffendorf (1998)
Seminars in Cardiothoracic and Vascular Anesthesia 2, 222-230
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Science. ISSN 0036-8075 (print), 1095-9203 (online)