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Science 23 August 1963:
Vol. 141. no. 3582, pp. 723 - 724
DOI: 10.1126/science.141.3582.723
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Articles

Dialysis Studies in Rats on the Long-Acting Antimalarial CI-501

J. A. Waitz 1, B. J. Olszewski 1, and P. E. Thompson 1

1 Research Division, Parke, Davis & Company, Ann Arbor, Michigan

Through the use of dialysis sacks, containing the repository antimalarial CI-501, implanted intraperitoneally into rats, evidence has been obtained indicating a local rather than a systemic reservoir of the drug. These results suggest that the repository activity of CI-501 is due to drug release from the injection site and that the probability of toxic effects resulting from storage or accumulation of the drug in vital organs is remote.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)