Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 23 August 1963:
Vol. 141. no. 3582, pp. 723 - 724
DOI: 10.1126/science.141.3582.723
Prev | Table of Contents | Next

Articles

Dialysis Studies in Rats on the Long-Acting Antimalarial CI-501

J. A. Waitz 1, B. J. Olszewski 1, and P. E. Thompson 1

1 Research Division, Parke, Davis & Company, Ann Arbor, Michigan

Through the use of dialysis sacks, containing the repository antimalarial CI-501, implanted intraperitoneally into rats, evidence has been obtained indicating a local rather than a systemic reservoir of the drug. These results suggest that the repository activity of CI-501 is due to drug release from the injection site and that the probability of toxic effects resulting from storage or accumulation of the drug in vital organs is remote.

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)