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Science 23 August 1963:
Vol. 141. no. 3582, pp. 717 - 718
DOI: 10.1126/science.141.3582.717
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Articles

Teratogenic Effect of 5-Hydroxytryptamine in Mice

Evelyn Poulson 1, J. M. Robson 1, and F. M. Sullivan 1

1 Department of Pharmacology, Guy's Hospital Medical School, London, S.E.I

The subcutaneous injection of a single dose of 5-hydroxytryptamine into pregnant mice produced a large number of fetal abnormalities, mostly of the eyes, limbs, and tail; the skull and central nervous system were also sometimes affected. These effects could result from the action of the drug on placental function and blood supply.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)