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Science 16 August 1963:
Vol. 141. no. 3581, pp. 649 - 650
DOI: 10.1126/science.141.3581.649
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Articles

Sex Chromatin Patterns and the Lyon Hypothesis

Robert DeMars 1

1 Department of Medical Genetics, University of Wisconsin, Madison 6

Polyploid human cells in culture often have paired sex chromatin masses. They are neither chance juxtapositions of randomly distributed X chromosomes nor manifestations of a propensity for pairing. The pairs are characteristic of the first polyploid interphase. They are thought to reflect the persistent differentiation of X chromosomes, as proposed in the Lyon hypothesis.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)