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Science 16 August 1963:
Vol. 141. no. 3581, pp. 642 - 643
DOI: 10.1126/science.141.3581.642
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Articles

Lactate Dehydrogenase Variant from Human Blood: Evidence for Molecular Subunits

Samuel H. Boyer 1, David C. Fainer 1, and E. J. Watson-Williams 2

1 Department of Medicine, Johns Hopkins Hospital and University School of Medicine, Baltimore 5, Maryland
2 University College Hospital, Ibadan, Nigeria

A variant of human lactate dehydrogenase is described. The occurrence of lactate dehydrogenase-1, -2, -3, and -4 as five, four, three, and two components, respectively, is interpreted as supporting the hypothesis that LDH isozymes are tetramers formed from various combinations of two types of subunits.


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