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Science 16 August 1963:
Vol. 141. no. 3581, pp. 631 - 633
DOI: 10.1126/science.141.3581.631
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Articles

Mosaic Histocompatibility of Skin Grafts from Female Mice

Donald W. Bailey 1

1 Cancer Research Institute, University of California School of Medicine, San Francisco

The histoincompatibility determined by one or more genes on the X chromosome of the mouse effects a complete rejection of skin of the (C57BL/6 female x BALB/c male) F1 hybrid male grafted onto the reciprocal type F1 hybrid male, but only an incomplete rejection of either reciprocal type F1 hybrid female skin, grafted onto the same type of male host. The resulting mosaic survival pattern of the female graft is interpreted as support for the Lyon hypothesis of X-chromosome inactivation.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)