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Science 16 August 1963:
Vol. 141. no. 3581, pp. 628 - 630
DOI: 10.1126/science.141.3581.628
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Articles

"Microsome" Fraction of Brain: Structural Changes Induced by Ascorbic Acid

G. K. Aghajanian 1

1 Department of Psychiatry, Yale University School of Medicine, New Haven, Coninecticut

The usual vesicular configuration of membrane fragments in the brain "microsome" fraction is radically altered by treatment with ascorbic acid and adenosine monophosphate. Lightscattering measurements and electron micrographs show that the treated membranes assume predominantly planar forms. This change in structure appears to be contingent upon a continued transport of electrons from ascorbic acid.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)