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Science 2 August 1963:
Vol. 141. no. 3579, pp. 427 - 429
DOI: 10.1126/science.141.3579.427
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Articles

Bioelectric Activity in Long-Term Cultures of Spinal Cord Tissues

Stanley M. Crain 1 and Edith R. Peterson 1

1 Departments of Anatomy, Neurology, and Surgery, College of Physicians and Surgeons, Columbia University, New York 32

Fragments of embryonic spinal cord (human, rat, and chick) can regenerate and differentiate in tissue culture. Complex bioelectric activity evoked by electric stimuli indicates that nerve cells in cultures may maintain, for months in vitro, not only the capacity to propagate impulses along their neurites but also a remarkable degree of functional organization resembling the activity of synaptic networks of the central nervous system.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Nerve growth factor attenuates neurotoxic effects of taxol on spinal cord-ganglion explants from fetal mice.
E. Peterson and S. Crain (1982)
Science 217, 377-379
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Development of specific sensory-evoked synaptic networks in fetal mouse cord-brainstem cultures.
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Organotypic Bioelectric Activity in Cultured Reaggregates of Dissociated Rodent Brain Cells.
S. M. Crain and M. B. Bornstein (1972)
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Ontogenetic Development of the Human Sleep-Dream Cycle.
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Functional Studies of Cultured Brain Tissues as Related to "Demyelinative Disorders".
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Microvibrations in Man and Dolphin.
M. Haider and D. B. Lindsley (1964)
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Science. ISSN 0036-8075 (print), 1095-9203 (online)