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Science 26 July 1963:
Vol. 141. no. 3578, pp. 359 - 360
DOI: 10.1126/science.141.3578.359
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Articles

Epizootic Diarrhea of Infant Mice: Identification of the Etiologic Agent

W. R. Adams 1 and L. M. Kraft 1

1 Department of Pathology, Yale University School of Medicine, New Haven, Connecticut

Electron micrographs of intestinal epithelium of infant mice infected with epizootic diarrhea virus have demonstrated intracellular spherical structures measuring 65 to 75 mµ in diameter which have a complex morphology resembling several virus particles. They have ben interpreted as being the etiologic agent of this disease. The particles were present in association with, in some cases within, vesicles of the endoplasmic reticulum of intestinal epithelial cells. They were never seen in the nucleus.


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J. Z. Chen, E. C. Settembre, S. T. Aoki, X. Zhang, A. R. Bellamy, P. R. Dormitzer, S. C. Harrison, and N. Grigorieff (2009)
PNAS 106, 10644-10648
   Abstract »    Full Text »    PDF »
Pathogenesis of Intestinal and Systemic Rotavirus Infection.
R. F. Ramig (2004)
J. Virol. 78, 10213-10220
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Science. ISSN 0036-8075 (print), 1095-9203 (online)