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Science 26 July 1963:
Vol. 141. no. 3578, pp. 353 - 355
DOI: 10.1126/science.141.3578.353
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Articles

Teratogenic Effects of Meclizine Hydrochloride on the Rat

C. T. G. King 1

1 National Institute of Dental Research, National Institutes of Health, Bethesda 14, Maryland

Congenital malformations were induced in the offspring of pregnant Sprague-Dawley rats by the admninistration of relatively large doses of meclizine hydrochloride (Bonine). The critical period of gestation for administration was from the 12th to 15th day. Anomalies were produced in the tongue, palatal closure, mouth, lower jaw, vertebrae and limbs.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Meclizine and Placebo in Treating Vertigo of Vestibular Origin: Relative Efficacy in a Double-Blind Study.
B. Cohen and J. M. B. V. deJong (1972)
Arch Neurol 27, 129-135
   Abstract »    PDF »
Teratogenic Effect of Meclizine, Cyclizine, and Chlorcyclizine.
J. F. Sadusk Jr. and P. A. Palmisano (1965)
JAMA 194, 987-989
   Abstract »    PDF »
Prenatal Factors and Their Evaluation.
U. Stave (1965)
Journal of Dental Research 44, 185-196
   PDF »
Environmental Variables in Disease.
(1964)
Science 146, 954-955
   PDF »
The Teratogenic Effect of the Steroid Nucleus in the Rat.
J. J. Buresh and T. J. Urban (1964)
Journal of Dental Research 43, 548-554
   PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)