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Science 28 June 1963:
Vol. 140. no. 3574, pp. 1400 - 1401
DOI: 10.1126/science.140.3574.1400
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Articles

Nitrogen Mustard: Diminution of Toxicity in Axenic Mice

Laurens P. White 1 and Elizabeth F. Claflin 1

1 Children's Cancer Research Foundation, Children's Medical Center, Boston 15, Massachusetts

Axenic, or germ-free, mice are more resistant to the delayed lethal effect of nitrogen mustard than normal mice. The resistance is most striking when mustard is administered at pH 2.0. The finding supports the hypothesis that intestinal bacteria play an important role in the systemic toxicity of nitrogen mustard.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Patient Protection in Cancer Chemotherapy.
S. A. Schwartz and S. Perry (1966)
JAMA 197, 623-627
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Science. ISSN 0036-8075 (print), 1095-9203 (online)