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Science 31 May 1963:
Vol. 140. no. 3570, pp. 987 - 988
DOI: 10.1126/science.140.3570.987
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Articles

Hypoglycemia: A Potent Stimulus to Secretion of Growth Hormone

Jesse Roth 1, Seymour M. Glick 1, Rosalyn S. Yalow 1, and Solomon A. Berson 1

1 Radioisotope Service, Veterans' Administration Hospital, Bronx 68, New York

In normal subjects, hypoglycemia produces an abrupt and sustained rise in levels of human growth hormone in plasma. This effect is independent of insulin, glucagon, or epinephrine. Prolonged fasting is accompanied by a rise in the hormone level in plasma. Measurement of this hormone after induced hypoglycemia is a specific test for pituitary somatotropic function.


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