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Science 17 May 1963:
Vol. 140. no. 3568, pp. 811 - 812
DOI: 10.1126/science.140.3568.811

Articles

Phosphorylase a Activity in Uterine Muscle: Stimulation by Ethylenediaminetetraacetic Acid

H. Philip Schane 1 and S. L. Leonard 1

1 Department of Zoology, Cornell University, Ithaca, New York

Injection of ethylenediaminetetraacetic acid into spayed rats or its use in phosphorylase extraction increases the activity of glycogen-phosphorylase a in uterine smooth muscle tissue. Since the total phosphorylase activity is not increased, the increase in phosphorylase a appears to result from a conversion of inactive phosphorylase b to the active form of the enzyme.





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Science. ISSN 0036-8075 (print), 1095-9203 (online)