Phosphorylase a Activity in Uterine Muscle: Stimulation by Ethylenediaminetetraacetic Acid
H. Philip Schane 1 and
S. L. Leonard 1
1 Department of Zoology, Cornell University, Ithaca, New York
Injection of ethylenediaminetetraacetic acid into spayed rats or its use in phosphorylase extraction increases the activity of glycogen-phosphorylase a in uterine smooth muscle tissue. Since the total phosphorylase activity is not increased, the increase in phosphorylase a appears to result from a conversion of inactive phosphorylase b to the active form of the enzyme.