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Science 10 May 1963:
Vol. 140. no. 3567, pp. 672 - 674
DOI: 10.1126/science.140.3567.672
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Articles

Angiotensinase with a High Degree of Specificity in Plasma and Red Cells

Philip A. Khairallah 1, F. Merlin Bumpus 1, Irvine H. Page 1, and Robert R. Smeby 1

1 Research Division, Cleveland Clinic Foundation, Cleveland, Ohio

A peptidase with a high degree of specificity for angiotensin II occurs in normal human plasma and red cells. Preparations from both sources have the same pH optimum, require calcium ions, and hydrolyze valyl5- or isoleucyl5-angiotensin II, but do not hydrolyze beta-aspartyl1-angiotensin II, arginyl1-angiotensin II or deaminoangiotensin II. This enzyme, given the name angiotensinase A, requires agr-L-aspartic acid or agr-L-asparagine as the N-terminal amino acid in its angiotensin substrate, and thus differs from kidney leucine aminopeptidase. Other peptidases known to hydrolyze angiotensin also hydrolyze at least one of the other angiotensin analogs with substitution in the one position.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Aminopeptidase-A. I. cDNA cloning and expression and localization in rat tissues.
M. Troyanovskaya, G. Jayaraman, L. Song, and D. P. Healy (2000)
Am J Physiol Regulatory Integrative Comp Physiol 278, R413-R424
   Abstract »    Full Text »    PDF »
Kidney Aminopeptidase A and Hypertension, Part I : Spontaneously Hypertensive Rats.
D. P. Healy and L. Song (1999)
Hypertension 33, 740-745
   Abstract »    Full Text »    PDF »
Kidney Aminopeptidase A and Hypertension, Part II : Effects of Angiotensin II.
L. Song and D. P. Healy (1999)
Hypertension 33, 746-752
   Abstract »    Full Text »    PDF »
Renin in the Diagnosis of Renovascular Hypertension: Activity in Renal and Peripheral Vein Plasma.
B. M. Winer, W. F. Lubbe, M. Simon, and J. A. Williams (1967)
JAMA 202, 121-128
   Abstract »    PDF »
Renal Erythropoietic Factor: Role of Ions and Vasoactive Agents in Erythropoietin Formation.
E. D. Zanjani, J. F. Contrera, G. W. Cooper, A. S. Gordon, and K. K. Wong (1967)
Science 156, 1367-1368
   Abstract »    PDF »
Plasma Angiotensinase Activity in Hypertensive Patients.
H. D. Itskovitz, S. J. Dudrick, I. Dyrda, and J. J. Murphy (1967)
Arch Intern Med 119, 241-246
   Abstract »    PDF »
Hypertensive Vascular Disease Produced by Homologous Renin.
G. M. C. Masson, C. Kashii, M. Matsunaga, and I. H. Page (1964)
Science 145, 178-180
   Abstract »    PDF »
Renal Baroceptor Control of Renin Secretion.
S. L. Skinner, J. W. McCubbin, and I. H. Page (1963)
Science 141, 814-816
   Abstract »    PDF »


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