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Science 3 May 1963:
Vol. 140. no. 3566, pp. 499 - 500
DOI: 10.1126/science.140.3566.499
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Articles

Enzymatic Formation of Adrenaline and Other Catechols from Monophenols

Julius Axelrod 1

1 National Institute of Mental Health, Bethesda, Maryland

An enzyme that forms adrenaline from p- and m-sympathol and dopamine from p- and m-tyramine is localized in the microsomes of rabbit liver and requires the reduced form of nicotinamide adenine dinucleotide phosphate. The enzyme is nonspecific and can form catechols from the following normally occurring and foreign phenols: p- and m-octopamine, p-hydroxyephedrine, phenol, stilbestrol, N-acetyl-p-aminophenol, estradiol and N-acetylserotonin.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Targeted Disruption of the Tyrosine Hydroxylase Locus Results in Severe Catecholamine Depletion and Perinatal Lethality in Mice.
K. Kobayashi, S. Morita, H. Sawada, T. Mizuguchi, K. Yamada, I. Nagatsu, T. Hata, Y. Watanabe, K. Fujita, and T. Nagatsu (1995)
J. Biol. Chem. 270, 27235-27243
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Catechol estrogens: presence in brain and endocrine tissues.
S. Paul and J Axelrod (1977)
Science 197, 657-659
   Abstract »    PDF »
l-Octopamine in Citrus: Isolation and Identification.
I. Stewart and T. A. Wheaton (1964)
Science 145, 60-61
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)