Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 26 April 1963:
Vol. 140. no. 3565, pp. 392 - 394
DOI: 10.1126/science.140.3565.392
Prev | Table of Contents | Next

Articles

Local Anesthetic Drugs: Penetration from the Spinal Extradural Space into the Neuraxis

P. R. Bromage 1, A. C. Joyal 1, and J. C. Binney 1

1 Department of Anaesthesia, Royal Victoria Hospital, Montreal, Quebec, Canada

Local anesthetics, injected into the spinal extradural space, can be recovered from the spinal cord and brain. Transport from the extradural space into the neuraxis is independent of an active circulation. Distribution is greatest in the periphery of the cord and is most intense near the site of injection. The drugs probably diffuse into the subperineural spaces of the mixed nerves and then pass centripetally along the spinal roots into the cerebrospinal fluid and the cord.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Analgesic Synergy Between Topical Morphine and Butamben in Mice.
Y. A. Kolesnikov, M. Cristea, and G. W. Pasternak (2003)
Anesth. Analg. 97, 1103-1107
   Abstract »    Full Text »    PDF »
Spinal Anesthesia.
F. J. Spielman and C. B. Watson (1983)
JAMA 249, 734-736
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)