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Science 12 April 1963:
Vol. 140. no. 3563, pp. 193 - 195
DOI: 10.1126/science.140.3563.193
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Articles

Passive Cutaneous Anaphylaxis with Antibody Fragments

Zoltan Ovary 1 and Angelo Taranta 1

1 Departments of Pathology and Medicine and Rheumatic Diseases Study Group, New York University School of Medicine, New York 16, and Irvington House, Irvington-on-Hudson, New York

Pepsin-digested rabbit antibody (5S) provoked reverse passive cutaneous anaphylaxis in the guinea pig, but was somewhat less effective, mole for mole, than the native antibody. Fixation of guinea pig complement by the pepsin-digested antibody could not be demonstrated either in vitro or in vivo. Splitting of the 5S fragment into two monovalent fragments (3.5S) markedly reduced the capacity to provoke reverse passive cutaneous anaphylaxis.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Complement-Fixing Properties of Pepsin-Treated Rabbit and Sheep Antibodies.
P. H. Schur and E. L. Becker (1963)
Science 141, 360-362
   Abstract »    PDF »
Antibody to Rat Kidney: In vivo Effects of Univalent and Divalent Fragments.
J. H. Baxter and P. A. Small Jr. (1963)
Science 140, 1406-1407
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)