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Science 12 April 1963:
Vol. 140. no. 3563, pp. 186 - 187
DOI: 10.1126/science.140.3563.186
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Articles

Methotrexate: Suppression of Experimental Allergic Encephalomyelitis

Michael W. Brandriss 1

1 National Institute of Allergy and Infectious Diseases, Bethesda, Maryland

Methotrexate inhibited the production of allergic encephalomyelitis in guinea pigs when administered between the time of sensitization and the onset of disease. If treatment was delayed until the day of onset of encephalomyelitis, the disease was still suppressed and the death rate was reduced. The protective effect of methotrexate was reversed by folinic acid.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Immunosuppression and the Guillain-Barre Syndrome.
D. A. Drachman, P. Y. Paterson, B. S. Berlin, and J. Roguska (1970)
Arch Neurol 23, 385-393
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Cyclophosphamide: Effect on Experimental Allergic Encephalomyelitis in Lewis Rats.
P. Y. Paterson and D. G. Drobish (1969)
Science 165, 191-192
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Cytotoxic Drugs in Steroid-Resistant Renal Disease: Alkylating and Antimetabolic Agents in the Treatment of Nephrotic Syndrome, Lupus Nephritis, Chronic Glomerulonephritis, and Purpura Nephritis in Children.
W. E. GRUPE and W. HEYMANN (1966)
Arch Pediatr Adolesc Med 112, 448-458
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Current Studies on the Effect of Antimetabolites in Nephrosis, Other Non-Neoplastic Diseases, and Experimental Animals: Combined Clinical Staff Conference at the National Institutes of Health.
H. C. GOODMAN, S. M. WOLFF, R. R. CARPENTER, B. R. ANDERSEN, and M. W. BRANDRISS (1963)
Ann Intern Med 59, 388-407
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Science. ISSN 0036-8075 (print), 1095-9203 (online)