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Science 12 April 1963:
Vol. 140. no. 3563, pp. 186 - 187
DOI: 10.1126/science.140.3563.186
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Articles

Methotrexate: Suppression of Experimental Allergic Encephalomyelitis

Michael W. Brandriss 1

1 National Institute of Allergy and Infectious Diseases, Bethesda, Maryland

Methotrexate inhibited the production of allergic encephalomyelitis in guinea pigs when administered between the time of sensitization and the onset of disease. If treatment was delayed until the day of onset of encephalomyelitis, the disease was still suppressed and the death rate was reduced. The protective effect of methotrexate was reversed by folinic acid.


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