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Science 12 April 1963:
Vol. 140. no. 3563, pp. 171 - 172
DOI: 10.1126/science.140.3563.171
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Articles

Homologous Disease Reactivation by X-radiation

Robert S. Schwartz 1 and Lorraine Beldotti 1

1 Pratt Clinic, New England Center Hospital, and Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts

Hybrid F1 mice (BDF1) that failed to develop homologous disease after injection of parental (C57 Bl/6) spleen cells were treated with 400 roentgens of total body x-radiation 13 months later. Typical homologous disease promptly developed in these mice. This suggests that parental lymphoid cells may acquire immunologic tolerance to "foreign" host antigens and that the tolerant state is disrupted by sublethal doses of radiation.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The Role of Immunologic Aberrations in the Pathogenesis of Lymphoma: With Particular Reference to Mycosis Fungoides and Exfoliative Erythroderma.
S. M. Bierman (1968)
Arch Dermatol 97, 699-711
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Science. ISSN 0036-8075 (print), 1095-9203 (online)