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Science 5 April 1963:
Vol. 140. no. 3562, pp. 60 - 62
DOI: 10.1126/science.140.3562.60
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Articles

Participation of an Intermediate of Oxidative Phosphorylation in Ion Accumulation by Mitochondria

G. P. Brierley 1, E. Murer 1, and D. E. Green 1

1 Institute for Enzyme Research, University of Wisconsin, Madison 6

Heart mitochondria accumulate massive amounts of Mg++ and phosphate or Ca++ and phosphate when incubated under appropriate conditions. Studies with inhibitors of respiration, oligomycin, and uncouplers of oxidative phosphorylation indicate that the energy necessary for these reactions may be provided either in the form of ATP in the absence of electron transport, or in the form of a high-energy intermediate of oxidative phosphorylation, which operates even though ATP is not produced.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Mitochondrial Ca2+ transport in frog early distal tubule.
M. R Fowler and M. Hunter (2005)
Exp Physiol 90, 195-201
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Science. ISSN 0036-8075 (print), 1095-9203 (online)