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Science 9 November 1962:
Vol. 138. no. 3541, pp. 691 - 693
DOI: 10.1126/science.138.3541.691
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Articles

Cholinergic Tracing of a Central Neural Circuit Underlying the Thirst Drive

Alan E. Fisher 1 and John N. Coury 1

1 Department of Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania

Cholinergic stimulation of any of a number of interrelated limbic and diencephalic structures in the rat elicits a rapid and marked increase in water intake. We postulate that a generalized Papez circuit mediates the thirst drive, that the circuit is specifically and functionally sensitive to cholinergic action, and that other primary drives depend on closely parallel neural circuits partitioned both structurally and biochemically.


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