Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 26 October 1962:
Vol. 138. no. 3539, pp. 523 - 525
DOI: 10.1126/science.138.3539.523
Prev | Table of Contents | Next

Articles

Angiotensin II: Its Metabolic Fate

P. A. Khairallah 1, Irvine H. Page 1, F. M. Bumpus 1, and R. R. Smeby 1

1 Research Division, Cleveland Clinic Foundation, Cleveland, Ohio

Randomly labeled tritiated angiotensin has been prepared with a specific activity of 300 µc/mg and with undiminished pressor and oxytocic activity. After infusion, angiotensin accumulated in the kidneys, adrenal glands, and uterus. Thirty minutes after infusion high levels of radioactivity appeared in brain, but the electrophoretic mobility differed from that of angiotensin II. Incubation of angiotensin with hemolyzed human red blood cells or diluted human plasma rapidly inactivated the pressor activity with production of metabolic products separable by paper chromatography. But if undiluted plasma is used with incubation up to 6 hours, no loss of activity occurs.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Increased Cardiovascular Reactivity to Angiotensin Caused by Renin.
G. M. C. Masson, K. Aoki, M. Matsunaga, and I. H. Page (1966)
Science 153, 1002-1004
   Abstract »    PDF »
Hypertensive Vascular Disease Produced by Homologous Renin.
G. M. C. Masson, C. Kashii, M. Matsunaga, and I. H. Page (1964)
Science 145, 178-180
   Abstract »    PDF »
Angiotensinase with a High Degree of Specificity in Plasma and Red Cells.
P. A. Khairallah, F. M. Bumpus, I. H. Page, and R. R. Smeby (1963)
Science 140, 672-674
   Abstract »    PDF »


ADVERTISEMENT
Click Me!

ADVERTISEMENT
Click Me!

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)