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Science 12 October 1962:
Vol. 138. no. 3537, pp. 143 - 144
DOI: 10.1126/science.138.3537.143
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Articles

Experimental Morphine Addiction: Method for Automatic Intravenous Injections in Unrestrained Rats

James R. Weeks 1

1 Upjohn Company, Kalamazoo, Michigan

An operant behavioral study on morphine addiction utilized a self-injection technique for giving intravenous injections to relatively unrestrained rats. The rate of self-injection varied inversely with the dose. Morphine was a reinforcer that produced almost immediate satiation.


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