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Science 28 September 1962:
Vol. 137. no. 3535, pp. 1058 - 1060
DOI: 10.1126/science.137.3535.1058
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Articles

Circadian Rhythm in the in vitro Response of Mouse Adrenal to Adrenocorticotropic Hormone

Frank Ungar 1 and Franz Halberg 1

1 Departments of Physiological Chemistry and Pathology, University of Minnesota, Minneapolis

Adrenal corticosterone production resulting from adrenocorticotropic hormone (ACTH) stimulation in vitro depends upon the time of gland removal. This rhythm in adrenal reactivity to ACTH is out of phase with the corticosterone rhythm in serum of the mice used as donors of adrenals. The responsiveness of the gland to exogenous ACTH is highest when serum corticosterone levels are lowest.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Periodicity of Susceptibility to Pneumococcal Infection: Influence of Light and Adrenocortical Secretions.
P. G. Shackelford and R. D. Feigin (1973)
Science 182, 285-287
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Science. ISSN 0036-8075 (print), 1095-9203 (online)