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Science 21 September 1962:
Vol. 137. no. 3534, pp. 982 - 983
DOI: 10.1126/science.137.3534.982
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Articles

Concurrent Morphological and Chemical Events in Staphylococcus aureus Exposed to Penicillin

Jennie Ciak 1 and Fred E. Hahn 1

1 Department of Molecular Biology, Walter Reed Army Institute of Research, Washington 12, D.C.

Disruption and lysis as well as accumulation of cell-wall precursor material have been demonstrated in several strains of Gram-positive cocci as results of the action of penicillin. The concurrence of these phenomena in typically penicillin-sensitive bacteria lends further support to the hypothesis that penicillin exerts its antibiotic action through interference with the formation of cell walls.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)