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Science 31 August 1962:
Vol. 137. no. 3531, pp. 688 - 689
DOI: 10.1126/science.137.3531.688
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Articles

Autoimmune Response in Rabbits Injected with Rat and Rabbit Liver Ribosomes

Matthew C. Dodd 1, Nancy J. Bigley 1, Virginia B. Geyer 1, Francis W. McCoy 1, and Henry E. Wilson 1

1 Departments of Microbiology and Medicine, Ohio State University, Columbus

Autoimmune hemolytic anemia and leukopenia, circulating autoantibodies for erythrocytes, leukocytes, and ribosomes; pathological changes in liver, spleen, heart, brain, and kidneys were produced in rabbits injected with rat or rabbit liver ribosomes. The hematologic and pathologic changes were reproduced by injection of anti-ribosomal serum into normal rabbits. The autoantibody specificity was related primarily to nucleotides and nucleosides.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)