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Science 24 August 1962:
Vol. 137. no. 3530, pp. 610 - 612
DOI: 10.1126/science.137.3530.610
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Articles

Staggerer, a New Mutation in the Mouse Affecting the Cerebellum

Richard L. Sidman 1, Priscilla W. Lane 2, and Margaret M. Dickie 2

1 Laboratory of Cellular Neuropathology, Harvard Medical School, Boston, Massachusetts
2 Roscoe B. Jackson Memorial Laboratory, Bar Harbor, Maine

The "staggerer" mutant is recognized by its staggering gait, mild tremor, hypotonia, and small size. Symptoms develop during postnatal weeks 1 to 4 and remain stationary thereafter. The cerebellar cortex is grossly underdeveloped, with too few granule cells and unaligned Purkinje cells. Genetic linkage studies and neuropathological findings distinguish staggerer from other known mutants.


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