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Science 24 August 1962:
Vol. 137. no. 3530, pp. 604 - 605
DOI: 10.1126/science.137.3530.604
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Articles

A Mehanism of the Indole Defect in Experimental Phenylketonuria

C. M. McKean 1, S. M. Schanberg 1, and N. J. Giarman 1

1 Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut

Rats made phenylketonuric by a diet containing high levels of either phenylalanine alone, or phenylalanine and tyrosine, show a marked reduction in total cerebral stores of serotonin. Evidence from studies both in vitro and in vivo indicates that an important mechanism of this impairment in the metabolism of serotonin is the inhibition by high levels of these amino acids of the active transport of the precursor of serotonin, 5-hydroxytryptophan, into brain.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Saturation of Blood Brain Barrier Transport of Amino Acids in Phenylketonuria.
W. H. Oldendorf (1973)
Arch Neurol 28, 45-48
   Abstract »    PDF »
Brain Uptake of Selenomethionine Se 75: I. Effects of Elevated Blood Levels of Methionine and Phenylalanine.
W. H. Oldendorf, W. B. Sisson, A. C. Mehta, and L. Treciokas (1971)
Arch Neurol 24, 423-430
   Abstract »    PDF »
Aminoacidemias: Effects on Maze Performance and Cerebral Serotonin.
C. M. McKean, S. M. Schanberg, and N. J. Giarman (1967)
Science 157, 213-215
   Abstract »    PDF »
5-Hydroxytryptophan Administration in Phenylketonuria.
T. L. PERRY and B. TISCHLER (1964)
Arch Pediatr Adolesc Med 107, 586-589
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)